Atlas Shrugged by Ayn Rand

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Description from Goodreads: "This is the story of a man who said that he would stop the motor of the world—and did. Was he a destroyer or the greatest of liberators? Why did he have to fight his battle, not against his enemies, but against those who needed him most, and his hardest battle against the woman he loved? What is the world's motor—and the motive power of every man? You will know the answer to these questions when you discover the reason behind the baffling events that play havoc with the lives of the characters in this story. This is a mystery story, not about the murder of a man's body, but about the murder—and rebirth—of man's spirit."

Finalist - 1958 National Book Award for Fiction

Check out the trailer for the the 2011 film.